Reba Howard

Rebecca J Howard, PhD



Structural basis for a bimodal allosteric mechanism of general anesthetic modulation in pentameric ligand-gated ion channels

Cell Reports 23: 993 - 1004, 2018

Fourati Z*, Howard RJ*, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M

*equal contributions

Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel

Journal of Neurochemistry 138: 243 - 253, 2016

Heusser SA, Yoluk Ö, Klement G, Riederer EA, Lindahl E, Howard RJ

Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and anesthetics

Pharmacological Reviews 66: 396 – 412, 2014

Howard RJ, Trudell JR, Harris RA

Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels

Molecular Pharmacology 84: 670 - 678, 2013

Heusser SA, Howard RJ, Borghese CM, Cullins MA, Brömstrup T, Lee US, Lindahl E, Carlsson J, Harris RA

Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites

Structure 21: 1307 - 1316, 2013

Brömstrup T, Howard RJ, Trudell JR, Harris RA, Lindahl E

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

Nature Communications 4: 1697, 2013

Sauguet L*, Howard RJ*, Malherbe L, Lee US, Corringer P-J, Harris RA, Delarue M

*equal contributions

Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia crysanthemi ligand-gated ion channel (ELIC)

Journal of Biological Chemistry 288: 8355 – 8364, 2013

Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price K, Weston D, Strelkov S, Tytgat J, Bertrand S, Bertrand D, Lummis S, Ulens C

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors

PLoS Computational Biology 8: e1002710, 2012

Murail S, Howard RJ, Broemstrup T, Bertaccini EJ, Harris RA, Trudell JR, Lindahl E

Structural insight into KCNQ (Kv7) channel assembly and channelopathy

Neuron 53: 663 – 675, 2007

Howard RJ, Clark KA, Holton JM, Minor DL

The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1

Molecular Cell 12: 1427 – 1437, 2003

Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL, Holton JM, Schulman BA

Ring-closing metathesis of olefinic peptides: design, synthesis, and structural characterization of macrocyclic helical peptides

Journal of Organic Chemistry 66: 5291 – 5302, 2001

Blackwell HE, Sadowsky JD, Howard RJ, Sampson JN, Chao JA, Steinmetz WE, O’Leary DJ, Grubbs RH

Selected Talks

Structural details of an allosteric mechanism for bimodal anesthetic modulation of pentameric ligand-gated ion channels

San Francisco, CA 2018

Biophysical Society

Alcohol at the interface: Functional and computational insights from prokaryotic Cys-loop receptors

New Orleans, LA 2016

Research Society on Alcoholism

Alcohol binding to ligand-gated ion channels revealed in a prokaryotic model system

Portland, ME 2013

University of New England

Alcohol modulation of ligand-gated ion channels: Insights and opportunities from new structures

Stockholm, Sweden 2013

Science for Life Laboratory

Simple structural models for alcohol modulation of ligand-gated ion channels

Albany, NY 2012

Albany Medical College

A combined functional-computational approach to characterizing structural sites of anesthetic modulation

San Diego, CA 2012

American Chemical Society

Structural basis for alcohol modulation of pentameric ligand-gated ion channels

San Francisco, CA 2012

Biophysical Society

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

Stockholm, Sweden 2011

Stockholm University